/* ─────────────────────────────────────────────────────────────
   Preliminary Manuscript stylesheet
   For the Clinical Frontier Portfolio dossier papers
   ───────────────────────────────────────────────────────────── */

@import url('https://fonts.googleapis.com/css2?family=EB+Garamond:ital,wght@0,400..800;1,400..800&family=JetBrains+Mono:wght@400;500;600&display=swap');

:root {
  --paper:      #fbf7ed;
  --paper-2:    #f4ecd8;
  --paper-3:    #ead9b3;
  --ink:        #1a1612;
  --ink-soft:   #41372c;
  --ink-faint:  #8a7c66;
  --rule:       #d6c8a8;
  --rule-soft:  #e3d8be;
  --accent:     #6a1f1f;
  --accent-2:   #8a3030;
  --sage:       #3d5240;
  --serif:      'EB Garamond', 'Crimson Pro', Georgia, 'Times New Roman', serif;
  --display:    'EB Garamond', Georgia, serif;
  --mono:       'JetBrains Mono', ui-monospace, 'SF Mono', Menlo, monospace;
}

[data-theme="dark"] {
  --paper:      #14110d;
  --paper-2:    #1d1812;
  --paper-3:    #2b231a;
  --ink:        #ece4d2;
  --ink-soft:   #c4baa0;
  --ink-faint:  #877c66;
  --rule:       #3a3122;
  --rule-soft:  #2a2318;
  --accent:     #d56861;
  --accent-2:   #e67d76;
  --sage:       #7fa07f;
}
[data-theme="dark"] body::before { opacity: 0.18; mix-blend-mode: screen; }
[data-theme="dark"] .node:hover rect,
[data-theme="dark"] .node:hover circle,
[data-theme="dark"] .node:hover polygon,
[data-theme="dark"] .node:hover path.shape {
  filter: drop-shadow(0 2px 6px rgba(213, 104, 97, 0.25));
}
[data-theme="dark"] .references li:target { background: rgba(213, 104, 97, 0.10); }
[data-theme="dark"] .callout { background: rgba(213, 104, 97, 0.08); }

/* ── THEME TOGGLE BUTTON ─────────────────────────────────── */
.theme-toggle {
  background: none;
  border: 1px solid var(--rule);
  color: var(--ink-soft);
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  padding: 5px 14px 5px 30px;
  cursor: pointer;
  position: relative;
  transition: all .2s ease;
  user-select: none;
}
.theme-toggle:hover {
  color: var(--accent);
  border-color: var(--accent);
}
.theme-toggle::before {
  content: '';
  position: absolute;
  left: 11px;
  top: 50%;
  transform: translateY(-50%);
  width: 12px;
  height: 12px;
  border-radius: 50%;
  background: var(--accent);
  box-shadow: inset -3px -3px 0 0 var(--paper);
  transition: all .25s ease;
}
[data-theme="dark"] .theme-toggle::before {
  background: var(--paper-3);
  box-shadow: inset -3px -3px 0 0 var(--accent);
}
.theme-toggle .label-light { display: inline; }
.theme-toggle .label-dark { display: none; }
[data-theme="dark"] .theme-toggle .label-light { display: none; }
[data-theme="dark"] .theme-toggle .label-dark { display: inline; }

* { box-sizing: border-box; margin: 0; padding: 0; }

html { scroll-behavior: smooth; }

body {
  background: var(--paper);
  color: var(--ink);
  font-family: var(--serif);
  font-size: 19px;
  line-height: 1.58;
  font-weight: 420;
  letter-spacing: 0.002em;
  font-feature-settings: "kern" 1, "liga" 1, "onum" 1, "hlig" 1;
  min-height: 100vh;
  position: relative;
}

/* subtle paper grain */
body::before {
  content: '';
  position: fixed;
  inset: 0;
  background-image: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 200 200'><filter id='n'><feTurbulence type='fractalNoise' baseFrequency='0.95' numOctaves='2' stitchTiles='stitch'/><feColorMatrix values='0 0 0 0 0.1 0 0 0 0 0.08 0 0 0 0 0.06 0 0 0 0.45 0'/></filter><rect width='100%' height='100%' filter='url(%23n)' opacity='0.45'/></svg>");
  opacity: 0.28;
  mix-blend-mode: multiply;
  pointer-events: none;
  z-index: 0;
}

main, header, footer, .top-bar { position: relative; z-index: 1; }

::selection { background: var(--accent); color: var(--paper); }

/* ── TOP BAR ─────────────────────────────────────────────────── */
.top-bar {
  border-bottom: 1px solid var(--rule);
  background: var(--paper);
  padding: 16px 36px;
  display: flex;
  justify-content: space-between;
  align-items: baseline;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--ink-faint);
}
.top-bar .back {
  color: var(--accent);
  text-decoration: none;
  transition: opacity .2s;
}
.top-bar .back:hover { opacity: 0.7; }
.top-bar .back::before { content: '←  '; }
.top-bar .meta { display: flex; gap: 28px; }
.top-bar .meta span { color: var(--ink-faint); }
.top-bar .meta strong { color: var(--accent); font-weight: 600; }

/* ── PAPER CONTAINER ────────────────────────────────────────── */
.paper {
  max-width: 740px;
  margin: 0 auto;
  padding: 84px 36px 96px;
}

/* ── TITLE BLOCK ────────────────────────────────────────────── */
.paper-id {
  text-align: center;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.28em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 32px;
}
.paper-id::before, .paper-id::after {
  content: '·';
  margin: 0 16px;
  color: var(--ink-faint);
}

.paper h1.title {
  font-family: var(--display);
  font-weight: 500;
  font-size: clamp(34px, 5vw, 44px);
  line-height: 1.08;
  letter-spacing: -0.012em;
  text-align: center;
  margin-bottom: 18px;
  text-wrap: balance;
}

.paper h1.title em {
  font-style: italic;
  color: var(--accent);
  font-weight: 460;
}

.paper .subtitle {
  font-family: var(--display);
  font-style: italic;
  font-weight: 420;
  text-align: center;
  font-size: 21px;
  line-height: 1.35;
  color: var(--ink-soft);
  margin: 0 auto 36px;
  max-width: 560px;
  text-wrap: balance;
}

.byline {
  text-align: center;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.18em;
  text-transform: uppercase;
  color: var(--ink-soft);
  margin-bottom: 52px;
  padding-bottom: 32px;
  border-bottom: 1px solid var(--rule);
}
.byline .author { color: var(--ink); font-weight: 600; }
.byline .affil { display: block; margin-top: 6px; color: var(--ink-faint); font-size: 10px; }
.byline .date { display: block; margin-top: 6px; color: var(--ink-faint); font-size: 10px; }

/* ── ABSTRACT ───────────────────────────────────────────────── */
.abstract {
  margin: 0 28px 56px;
  font-style: italic;
  font-size: 16.5px;
  line-height: 1.6;
  color: var(--ink-soft);
  text-align: justify;
  hyphens: auto;
}
.abstract::first-letter {
  font-style: normal;
  font-weight: 600;
  color: var(--ink);
}
.abstract-label {
  display: block;
  font-style: normal;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.24em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 10px;
  text-align: center;
}

/* ── SECTIONS ───────────────────────────────────────────────── */
.paper h2 {
  font-family: var(--display);
  font-weight: 560;
  font-size: 22px;
  line-height: 1.2;
  letter-spacing: -0.006em;
  margin: 44px 0 16px;
  display: flex;
  align-items: baseline;
  gap: 14px;
}
.paper h2 .secnum {
  font-family: var(--mono);
  font-size: 12px;
  font-weight: 600;
  color: var(--accent);
  letter-spacing: 0.06em;
}

.paper h3 {
  font-family: var(--display);
  font-weight: 540;
  font-style: italic;
  font-size: 18px;
  line-height: 1.25;
  margin: 26px 0 10px;
}
.paper h3 .subsecnum {
  font-family: var(--mono);
  font-size: 11px;
  font-style: normal;
  color: var(--accent);
  margin-right: 6px;
}

/* ── BODY TEXT ─────────────────────────────────────────────── */
.paper p {
  text-align: justify;
  text-justify: inter-word;
  hyphens: auto;
  margin-bottom: 14px;
  -webkit-hyphens: auto;
  -ms-hyphens: auto;
}

.paper p + p {
  text-indent: 1.4em;
  margin-top: -8px;
}

.paper p.lead, .paper p.no-indent {
  text-indent: 0;
  margin-top: 0;
}

.paper em { font-style: italic; }
.paper strong { font-weight: 620; }

.paper a {
  color: var(--accent);
  text-decoration: underline;
  text-decoration-thickness: 0.5px;
  text-underline-offset: 2px;
}
.paper a:hover { color: var(--accent-2); }

/* citation superscripts */
.paper sup.cite, .paper a.cite {
  font-family: var(--serif);
  font-feature-settings: "sups" 1;
  font-size: 0.82em;
  color: var(--accent);
  text-decoration: none;
  vertical-align: super;
  line-height: 0;
  letter-spacing: 0.02em;
  font-weight: 500;
  padding: 0 1px;
}
.paper a.cite:hover { text-decoration: underline; text-underline-offset: 2px; }

/* ── LISTS ─────────────────────────────────────────────────── */
.paper ol, .paper ul {
  margin: 10px 0 16px 0;
  padding-left: 1.8em;
}
.paper li {
  margin-bottom: 8px;
  text-align: justify;
  hyphens: auto;
}

/* ── CALLOUTS ──────────────────────────────────────────────── */
.callout {
  margin: 20px 0;
  padding: 18px 26px;
  background: var(--paper-2);
  border-left: 2px solid var(--accent);
  font-size: 17px;
  line-height: 1.55;
}
.callout-label {
  display: block;
  font-family: var(--mono);
  font-size: 9.5px;
  letter-spacing: 0.26em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 8px;
}

/* ── INLINE TECHNICAL ─────────────────────────────────────── */
.paper code, .paper .mono {
  font-family: var(--mono);
  font-size: 0.88em;
  background: var(--paper-2);
  padding: 1px 6px;
  border-radius: 2px;
  letter-spacing: 0.01em;
}

/* ── EQUATION / DISPLAY BLOCKS ───────────────────────────── */
.display-block {
  margin: 18px 0;
  padding: 18px 24px;
  background: var(--paper-2);
  border: 1px solid var(--rule-soft);
  font-family: var(--mono);
  font-size: 13px;
  line-height: 1.6;
  white-space: pre-wrap;
}

/* ── TABLES ────────────────────────────────────────────────── */
.paper table {
  width: 100%;
  margin: 20px 0;
  border-collapse: collapse;
  font-size: 15px;
}
.paper table caption {
  font-style: italic;
  text-align: left;
  margin-bottom: 8px;
  color: var(--ink-soft);
  font-size: 14px;
}
.paper table caption strong {
  font-style: normal;
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  color: var(--accent);
  margin-right: 8px;
}
.paper th, .paper td {
  padding: 8px 12px;
  border-bottom: 1px solid var(--rule-soft);
  text-align: left;
  vertical-align: top;
}
.paper th {
  border-top: 1px solid var(--ink);
  border-bottom: 1px solid var(--ink);
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  font-weight: 600;
  color: var(--ink);
}
.paper tr:last-child td { border-bottom: 1px solid var(--ink); }

/* ── REFERENCES ────────────────────────────────────────────── */
.references {
  margin-top: 64px;
  padding-top: 32px;
  border-top: 2px solid var(--ink);
}
.references h2 {
  font-size: 19px;
  margin: 0 0 20px;
  font-weight: 600;
}
.references ol {
  list-style: none;
  margin: 0;
  padding: 0;
  counter-reset: ref;
}
.references li {
  counter-increment: ref;
  font-size: 14px;
  line-height: 1.5;
  padding: 9px 0 9px 44px;
  position: relative;
  text-align: left;
  border-bottom: 1px dotted var(--rule-soft);
  scroll-margin-top: 80px;
}
.references li:target {
  background: rgba(106, 31, 31, 0.06);
}
.references li:last-child { border-bottom: none; }
.references li::before {
  content: '[' counter(ref) ']';
  position: absolute;
  left: 0;
  top: 9px;
  font-family: var(--mono);
  font-size: 12px;
  color: var(--accent);
  font-weight: 600;
}
.references li em { font-style: italic; }
.references li a.doi {
  display: inline-block;
  margin-top: 2px;
  font-family: var(--mono);
  font-size: 11px;
  color: var(--accent);
  word-break: break-word;
  text-decoration: none;
  letter-spacing: 0.01em;
}
.references li a.doi:hover { text-decoration: underline; text-underline-offset: 2px; }

/* ── COLOPHON ──────────────────────────────────────────────── */
.colophon-line {
  margin-top: 72px;
  padding-top: 28px;
  border-top: 1px solid var(--rule);
  text-align: center;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.22em;
  text-transform: uppercase;
  color: var(--ink-faint);
  line-height: 2;
}
.colophon-line .ornament {
  display: block;
  font-family: var(--display);
  font-size: 18px;
  font-style: italic;
  color: var(--accent);
  margin-bottom: 12px;
  letter-spacing: 0;
  text-transform: none;
}

/* ─────────────────────────────────────────────────────────────
   INTERACTIVE DIAGRAMS
   ───────────────────────────────────────────────────────────── */

.diagram {
  margin: 36px -20px;
  padding: 32px 28px 24px;
  background: var(--paper-2);
  border-top: 1px solid var(--rule);
  border-bottom: 1px solid var(--rule);
  position: relative;
}
.diagram .fig-label {
  font-family: var(--mono);
  font-size: 9.5px;
  letter-spacing: 0.26em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 14px;
}
.diagram svg {
  display: block;
  width: 100%;
  height: auto;
  max-width: 720px;
  margin: 0 auto;
  overflow: visible;
}
.diagram figcaption {
  font-size: 14px;
  font-style: italic;
  color: var(--ink-soft);
  line-height: 1.55;
  margin-top: 20px;
  padding-top: 14px;
  border-top: 1px dotted var(--rule);
  text-align: justify;
}
.diagram figcaption strong {
  font-style: normal;
  color: var(--accent);
  font-family: var(--mono);
  font-size: 11px;
  letter-spacing: 0.16em;
  text-transform: uppercase;
  margin-right: 8px;
}

/* SVG node primitives */
.node rect, .node circle, .node polygon, .node path.shape {
  fill: var(--paper);
  stroke: var(--ink);
  stroke-width: 1.4;
  transition: all .25s cubic-bezier(.4, 0, .2, 1);
}
.node:hover rect,
.node:hover circle,
.node:hover polygon,
.node:hover path.shape {
  fill: var(--paper-3);
  stroke: var(--accent);
  stroke-width: 1.8;
  filter: drop-shadow(0 2px 4px rgba(106, 31, 31, 0.18));
}
.node.accent rect, .node.accent circle, .node.accent polygon {
  fill: rgba(106, 31, 31, 0.08); stroke: var(--accent);
}
.node.sage rect, .node.sage circle, .node.sage polygon {
  fill: rgba(61, 82, 64, 0.08); stroke: var(--sage);
}

.node text {
  font-family: var(--display);
  font-size: 14px;
  fill: var(--ink);
  pointer-events: none;
  text-anchor: middle;
  dominant-baseline: middle;
}
.node text.title { font-weight: 580; font-size: 15px; }
.node text.sub {
  font-size: 11px;
  font-style: italic;
  fill: var(--ink-soft);
}
.node text.mono {
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.04em;
  fill: var(--ink-faint);
  text-transform: uppercase;
}

/* Flow arrows */
.flow-arrow {
  fill: none;
  stroke: var(--accent);
  stroke-width: 1.5;
  marker-end: url(#arrowhead);
}
.flow-arrow.dashed { stroke-dasharray: 4 3; }
.flow-arrow.return { stroke: var(--ink-faint); stroke-dasharray: 2 3; }
.flow-arrow.thin { stroke-width: 1; }

.flow-label {
  font-family: var(--mono);
  font-size: 9.5px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  fill: var(--ink-soft);
  text-anchor: middle;
}

/* Animated flow path */
@keyframes flow-dash {
  to { stroke-dashoffset: -40; }
}
.flow-anim {
  stroke-dasharray: 6 4;
  animation: flow-dash 1.8s linear infinite;
}

/* Pulsing emphasis */
@keyframes pulse-stroke {
  0%, 100% { stroke-opacity: 1; }
  50% { stroke-opacity: 0.45; }
}
.pulse { animation: pulse-stroke 2.6s ease-in-out infinite; }

/* Pipeline stage cards */
.stage rect {
  fill: var(--paper);
  stroke: var(--ink);
  stroke-width: 1.4;
  transition: all .2s ease;
}
.stage:hover rect {
  fill: var(--paper-3);
  stroke: var(--accent);
}
.stage-num {
  font-family: var(--mono);
  font-size: 11px;
  font-weight: 600;
  fill: var(--accent);
}

/* Expandable detail panel */
.diagram-detail {
  margin-top: 18px;
  padding: 14px 18px;
  background: var(--paper);
  border-left: 2px solid var(--accent);
  font-size: 14px;
  line-height: 1.55;
}
.diagram-detail summary {
  cursor: pointer;
  font-family: var(--mono);
  font-size: 10px;
  letter-spacing: 0.22em;
  text-transform: uppercase;
  color: var(--accent);
  font-weight: 600;
  list-style: none;
  outline: none;
}
.diagram-detail summary::before {
  content: '▸ ';
  display: inline-block;
  transition: transform .2s ease;
  margin-right: 4px;
}
.diagram-detail[open] summary::before { transform: rotate(90deg); }
.diagram-detail summary::-webkit-details-marker { display: none; }
.diagram-detail p {
  margin-top: 10px;
  font-style: italic;
  color: var(--ink-soft);
}

/* Numbered annotation badges */
.annotation circle {
  fill: var(--accent);
  stroke: var(--paper);
  stroke-width: 1.5;
}
.annotation text {
  fill: var(--paper);
  font-family: var(--mono);
  font-size: 9.5px;
  font-weight: 700;
  text-anchor: middle;
  dominant-baseline: central;
}

/* ── RESPONSIVE ───────────────────────────────────────────── */
@media (max-width: 700px) {
  .paper { padding: 56px 24px 72px; }
  .paper h1.title { font-size: 30px; }
  .abstract { margin-left: 0; margin-right: 0; }
  .top-bar { padding: 14px 22px; flex-direction: column; gap: 6px; align-items: flex-start; }
  .top-bar .meta { gap: 16px; flex-wrap: wrap; }
  body { font-size: 17px; }
  .paper-id::before, .paper-id::after { display: none; }
  .diagram { margin: 28px -16px; padding: 22px 18px 18px; }
  .diagram svg { font-size: 9px; }
}